Ceftazidime , 10mMinWater , 72558-82-8

Synonym(s):
1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum;Ceftazidime pentahydrate

CAS NO.：72558-82-8

Empirical Formula: C22H22N6O7S2

Molecular Weight: 546.58

MDL number: MFCD00072034

EINECS: 276-715-9

PRODUCT Properties

• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• solubility: ≥21.25 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
• form: powder to crystal
• color: White to Orange to Green
• Merck: 14,1946
• Stability: Stable, but keep refrigerated. Incompatible with strong oxidizing agents, nitric acid, permanganates, peroxides.

Description and Uses

In ceftazidime the oxime moiety is more complex, containing two methyl groups and a carboxylic acid. This assemblage conveys even more pronounced β-lactamase stability, greater anti–Pseudomonas aerugi nosa, and increased activity against Gram-positive organisms. The C-3 side chain has been replaced by a charged pyridinium moiety. The latter considerably enhances water solubility and also highly activates the β-lactam bond toward cleavage. The drug must be protected against heat and light and may darken without significant loss of potency. It is not stable under some conditions. such as the presence of aminoglycosides and vancomycin. It also is attacked readily in sodium bicarbonate solutions. Resistance is mediated by chromosomally mediated β-lactamases and by lack of penetration into target bacteria. Otherwise, it has a very broad antibacterial spectrum.

pyrimidine synthesis inhibitor disease-modifying antirheumatic drug

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P272-P280-P284-P302+P352+P333+P313+P363-P304+P340+P342+P311-P501
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• RTECS: UU2225000
• HS Code: 29419000