5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide , 10mMinDMSO , 16673-34-0

Synonym(s):
4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzene sulfonamide;4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide;5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide

CAS NO.：16673-34-0

Empirical Formula: C16H17ClN2O4S

Molecular Weight: 368.84

MDL number: MFCD00193756

EINECS: 240-722-5

PRODUCT Properties

• Melting point: 209-214 °C
• Density: 1.356±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 45 mg/ml).
• form: Solid
• pka: 10.14±0.10(Predicted)
• color: White
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
• InChI: InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
• InChIKey: KVWWTCSJLGHLRM-UHFFFAOYSA-N
• SMILES: C(NCCC1=CC=C(S(N)(=O)=O)C=C1)(=O)C1=CC(Cl)=CC=C1OC

Description and Uses

NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising?in vivo?protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2?Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2

An impurity arising in the synthesis of Glyburide (G598350).

Safety

• Hazard Codes: T
• Risk Statements: 23-24-25
• Safety Statements: 24/25
• WGK Germany: 1
• HS Code: 2935909550