astemizole , 10mMinDMSO , 68844-77-9

Synonym(s):
1-(4-Fluorobenzyl)-2-(1-[4-methoxyphenethyl]piperidin-4-yl)aminobenzimidazole

CAS NO.：68844-77-9

Empirical Formula: C28H31FN4O

Molecular Weight: 458.57

MDL number: MFCD00153919

EINECS: 272-441-9

PRODUCT Properties

• Melting point: 172.9°C
• Boiling point: 627.3±65.0 °C(Predicted)
• Density: 1.1587 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: >20mg/mL
• pka: pKa 4.85(H2O t=25.0 I=0.025) (Uncertain);8.69(H2O t=25.0 I=0.025) (Uncertain)
• form: powder
• color: Crystals
• Water Solubility: It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Description and Uses

Astemizole belongs to the second-generation class of non-sedating, non-anticholinergic antihistamines. Its non-sedating properties appear to result from its poor penetration of the blood brain barrier. As a result it shows no potentiation of CNS depressants, including alcohol. Its long half-life allows once-daily dosing.

Astemizole is used for preventing and treating severe seasonal and chronic allergic rhinitis, allergic conjunctivitis, hives, Quinke’s edema, other allergic conditions and dermatitis. Synonyms of this drug are hismanal, histazol, and others.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1 / PGII
• WGK Germany: 3
• RTECS: DD8968000
• HS Code: 2933992600
• Toxicity: LD50 orl-rat: >2560 mg/kg AIPTAK 251,39,81