Abacavir , 10mMinDMSO , 136470-78-5
CAS NO.：136470-78-5
Empirical Formula: C14H18N6O
Molecular Weight: 286.33
MDL number: MFCD00903850
EINECS: 620-487-9
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 165° |
| alpha | D20 -59.7°; 43620 -127.8°; 36520 -218.1° (c = 0.15 in methanol) |
| Boiling point: | 636.0±65.0 °C(Predicted) |
| Density | 1.70±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| pka | 5.01(at 25℃) |
| form | Solid |
| color | Off-White to Pale Beige |
| Merck | 14,1 |
| BCS Class | 3 |
| CAS DataBase Reference | 136470-78-5(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)- (136470-78-5) |
Description and Uses
The drug is extensively metabolized via stepwise phosphorylation to 5′-mono-, di-, and triphosphate. Abacavir is well absorbed (>75%) and penetrates the CNS. The drug can be taken without regard to meals. The drug does not show any clinically significant drug–drug interactions. Abacavir has been reported to produce life-threatening hypersensitivity reactions. The major use of abacavir appears to be in combination with other nucleoside RT inhibitors. A fixed-combination product has recently been approved by the U.S. FDA consisting of 300 mg of ABC, 150 mg of 3TC, and 300 mg of ZDV (Trizivar). The combination has been shown to be superior to other combinations in reducing viral load as well as to show improvement in CD4 cell count.
A nucleoside reverse transcriptase inhibitor (NRTI).
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H361-H317-H334-H341 |
| Precautionary statements | P501-P261-P272-P202-P201-P280-P284-P302+P352-P308+P313-P362+P364-P304+P340-P333+P313-P405 |
| RTECS | GY5979200 |
| HS Code | 2933.99.7500 |
