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A7038158

Abacavir , 10mMinDMSO , 136470-78-5

CAS NO.:136470-78-5

Empirical Formula: C14H18N6O

Molecular Weight: 286.33

MDL number: MFCD00903850

EINECS: 620-487-9

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 165°
alpha  D20 -59.7°; 43620 -127.8°; 36520 -218.1° (c = 0.15 in methanol)
Boiling point: 636.0±65.0 °C(Predicted)
Density  1.70±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly, Heated), Methanol (Slightly)
form  Solid
pka 5.01(at 25℃)
color  Off-White to Pale Beige
Merck  14,1
BCS Class 3

Description and Uses

The drug is extensively metabolized via stepwise phosphorylation to 5′-mono-, di-, and triphosphate. Abacavir is well absorbed (>75%) and penetrates the CNS. The drug can be taken without regard to meals. The drug does not show any clinically significant drug–drug interactions. Abacavir has been reported to produce life-threatening hypersensitivity reactions. The major use of abacavir appears to be in combination with other nucleoside RT inhibitors. A fixed-combination product has recently been approved by the U.S. FDA consisting of 300 mg of ABC, 150 mg of 3TC, and 300 mg of ZDV (Trizivar). The combination has been shown to be superior to other combinations in reducing viral load as well as to show improvement in CD4 cell count.

A nucleoside reverse transcriptase inhibitor (NRTI).

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H361-H317-H334-H341
Precautionary statements  P501-P261-P272-P202-P201-P280-P284-P302+P352-P308+P313-P362+P364-P304+P340-P333+P313-P405
RTECS  GY5979200
HS Code  2933.99.7500

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