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A7036758

ChloroquinePhosphate , 10mMinWater , 50-63-5

Synonym(s):
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt;Chloroquine diphosphate salt;N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine diphosphate

CAS NO.:50-63-5

Empirical Formula: C18H32ClN3O8P2

Molecular Weight: 515.86

MDL number: MFCD00069852

EINECS: 200-055-2

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 200 °C (dec.) (lit.)
storage temp.  protect from light
solubility  H2O: 50 mg/mL, clear
form  solid
pka pKa 8.10(H2O t = 20 c = 0.0025) (Uncertain)
color  White
PH pH(100g/l, 25℃) : 3.8~4.3
Water Solubility  Soluble in water
Merck  14,2163
BRN  4223142
BCS Class 1
Stability: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
InChIKey QKICWELGRMTQCR-UHFFFAOYSA-N

Description and Uses

Chloroquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial, anti-inflammatory, anticancer, and antiviral activities. Chloroquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 μM. It is active against the chloroquine-sensitive GC03 strain of P. falciparum (IC50 = 29.2 nM) but has decreased activity against mutant pfcrt P. falciparum (IC50s = 100-150 nM). Chloroquine prevents infection by severe acute respiratory coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 1.13 μM) but does not inhibit SARS-CoV replication in the lungs in a mouse model of SARS-CoV infection. It inhibits the growth of human SSC25 and CAL 27 oral squamous cell carcinoma cells (IC50s = 29.9 and 17.3 μM, respectively), as well as A498, SN12C, RXF 393, and 769-P renal cancer cells (IC50s = 16, 62, 81, and 25 μM, respectively). It reduces tumor growth in a CAL 27 mouse xenograft model and a 4T1 mouse allograft model when administered at a dose of 50 mg/kg. Formulations containing chloroquine have been used in the prevention of malaria, as well as the treatment of rheumatoid arthritis and systemic lupus erythematosus (SLE), and have been associated with cardiotoxicity and myopathy.

An antimalarial compound

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22-40-20/21/22
Safety Statements  22-24/25-36
RIDADR  1544
WGK Germany  3
RTECS  VB2450000
10
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933492250
Toxicity LD50 oral in rat: 623mg/kg

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