Home Categories API Cefoperazonesodium
A7036358

Cefoperazonesodium , 10mMinDMSO , 62893-20-3

CAS NO.:62893-20-3

Empirical Formula: C25H28N9NaO8S2

Molecular Weight: 669.66

MDL number: MFCD07793331

EINECS: 263-751-5

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 200-202°C
storage temp.  Inert atmosphere,2-8°C
solubility  H2O: 50 mg/mL, clear, faintly yellow
form  powder
color  White to Off-White
Water Solubility  Soluble in water. Slightly soluble in alcohol.
Merck  13,1943
BRN  4902135
Stability: Hygroscopic
InChIKey NCFTXMQPRQZFMZ-WERGMSTESA-M
SMILES C(C1=C(CS[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)NC(N3CCN(CC)C(=O)C3=O)=O)C(=O)N12)CSC1=NN=NN1C)(=O)O.[NaH] |&1:5,7,11,r|
CAS DataBase Reference 62893-20-3(CAS DataBase Reference)

Description and Uses

Cefoperazone was synthesized by Toyama Chemicals Co. in 1978. Except for the hydroxyl group, the side chain attached to the cephem nucleus is the same as that of piperacillin. Cefoperazone shows excellent activity against gram-positive (except Staphylococcus) and gram- negative bacteria, including Pseudomonas aeruginosa. Its pharmacological characteristics are unique. Cefoperazone is excreted mainly in bile, and a concentration five to tenfold higher in bile than in serum is obtained. The transfer into cerebrospinal fluid is 10 – 30 % of the serum concentration; the half-life in serum is 2.0 – 2.6h, and the degree of binding with serum protein is as high as 86.6 %.

For studying the expression, binding, and inhibition of penicillin-binding proteins.Cefoperazone sodium salt is used in the study of drug-protein binding, expression and inhibition of penicillin-binding proteins during cell wall synthesis. It is as an antibacterial and antimicrobial agent useful for prevention of postoperative infection. It is used as an inhibitor of inactivation of alfa-antitrypsin.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P342+P311
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  22-36/37
WGK Germany  2
RTECS  XI0374000
HS Code  29419000

RELATED PRODUCTS