Cefoperazonesodium , 10mMinDMSO , 62893-20-3

CAS NO.：62893-20-3

Empirical Formula: C25H28N9NaO8S2

Molecular Weight: 669.66

MDL number: MFCD07793331

EINECS: 263-751-5

PRODUCT Properties

• Melting point: 200-202°C
• storage temp.: Inert atmosphere,2-8°C
• solubility: H₂O: 50 mg/mL, clear, faintly yellow
• form: powder
• color: White to Off-White
• Water Solubility: Soluble in water. Slightly soluble in alcohol.
• Merck: 13,1943
• BRN: 4902135
• Stability: Hygroscopic
• InChIKey: NCFTXMQPRQZFMZ-WERGMSTESA-M
• SMILES: C(C1=C(CS[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)NC(N3CCN(CC)C(=O)C3=O)=O)C(=O)N12)CSC1=NN=NN1C)(=O)O.[NaH] |&1:5,7,11,r|

Description and Uses

Cefoperazone was synthesized by Toyama Chemicals Co. in 1978. Except for the hydroxyl group, the side chain attached to the cephem nucleus is the same as that of piperacillin. Cefoperazone shows excellent activity against gram-positive (except Staphylococcus) and gram- negative bacteria, including Pseudomonas aeruginosa. Its pharmacological characteristics are unique. Cefoperazone is excreted mainly in bile, and a concentration five to tenfold higher in bile than in serum is obtained. The transfer into cerebrospinal fluid is 10 – 30 % of the serum concentration; the half-life in serum is 2.0 – 2.6h, and the degree of binding with serum protein is as high as 86.6 %.

For studying the expression, binding, and inhibition of penicillin-binding proteins.Cefoperazone sodium salt is used in the study of drug-protein binding, expression and inhibition of penicillin-binding proteins during cell wall synthesis. It is as an antibacterial and antimicrobial agent useful for prevention of postoperative infection. It is used as an inhibitor of inactivation of alfa-antitrypsin.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P280-P342+P311
• Hazard Codes: Xn
• Risk Statements: 42/43
• Safety Statements: 22-36/37
• WGK Germany: 2
• RTECS: XI0374000
• HS Code: 29419000