CefpodoximeProxetil , 10mMinDMSO , 87239-81-4

Synonym(s):
(RS)1(isopropoxycarbonyloxy) ethyl (+)-(6R,7R)-7-[2-(2-amino-4- thiazolyl)-2-{(Z)methoxyimino}acetamido]-3methoxymethyl-8-oxo-5-thia-1-azabicyclo [4.2.0]oct-2-ene- 2-carboxylate;Cefpodoxime proxetil

CAS NO.：87239-81-4

Empirical Formula: C21H27N5O9S2

Molecular Weight: 557.6

MDL number: MFCD00865088

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 111-113°C
• Density: 1.58±0.1 g/cm3(Predicted)
• RTECS: XI0367370
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO
• pka: 8.13±0.60(Predicted)
• form: Solid
• color: White to Pale Yellow
• Sensitive: Light Sensitive
• InChIKey: LTINZAODLRIQIX-FBXRGJNPSA-N
• SMILES: N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\OC)=O)C1=O)SCC(COC)=C2C(OC(OC(OC(C)C)=O)C)=O

Description and Uses

Cefpodoxime proxetil is an orally active, broad-spectrum cephalosporin especially useful in the treatment of bacterial infections in children. It is a prodrug converted by esterases in the GI walls to cefpodoxime, which reportedly has a bacteriostatic spectrum comparable to injectable third-generation cephem antibiotics.

A metabolite of Cefpodoxime Proxetil. An antibacterial.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H317-H334
• Precautionary statements: P261-P280g-P284-P304+P340-P342+P311a-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38-42/43
• Safety Statements: 22-26-36/37/39
• WGK Germany: 3
• HS Code: 30042000
• Toxicity: LD50 in male, female mice, male, female rats (mg/kg): >10000, >10000, >2000, >2000 s.c., 3502, 2535, >4000, >4000 i.p.; >8000, >8000, >4000, >4000 orally (Nakao, 1988)