Home Categories Biochemical Engineering CucurbitacinB
A7024058

CucurbitacinB , 10mMinDMSO , 6199-67-3

Synonym(s):
(2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione

CAS NO.:6199-67-3

Empirical Formula: C32H46O8

Molecular Weight: 558.7

MDL number: MFCD07778083

Pack Size Price Stock Quantity
1ml RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 184-186°
alpha  D25 +88° (c = 1.55 in ethanol)
Boiling point: 546.74°C (rough estimate)
Density  1.0953 (rough estimate)
refractive index  1.4900 (estimate)
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  DMSO: soluble10mg/mL, clear
form  powder
pka 12.60±0.29(Predicted)
color  white to beige
λmax 290nm(EtOH)(lit.)
Merck  14,2614
Stability: Hygroscopic
InChIKey IXQKXEUSCPEQRD-ALLWXVAWSA-N

Description and Uses

Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.

Cucurbitacin B hydrate has been used:

  • as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
  • as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
  • to determine its effect on the cell viability of pancreatic cancer cell lines.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  T
Risk Statements  25
Safety Statements  45-24/25
RIDADR  UN 2811 6.1 / PGI
WGK Germany  3
RTECS  RC6190000
HazardClass  6.1
PackingGroup  II
HS Code  29153900
Hazardous Substances Data 6199-67-3(Hazardous Substances Data)
Toxicity LD10 orally in mice: 5 mg/kg (LeMen)

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