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A7018758

Benzbromarone , 10mMinDMSO , 3562-84-3

Synonym(s):
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran

CAS NO.:3562-84-3

Empirical Formula: C17H12Br2O3

Molecular Weight: 424.08

MDL number: MFCD00078962

EINECS: 222-630-7

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 151°
Boiling point: 514.1±50.0 °C(Predicted)
Density  1.6211 (rough estimate)
refractive index  1.6010 (estimate)
storage temp.  Inert atmosphere,2-8°C
solubility  Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent).
pka 4.66±0.25(Predicted)
form  Solid
color  White to Light yellow
Merck  14,1065
InChIKey WHQCHUCQKNIQEC-UHFFFAOYSA-N
CAS DataBase Reference 3562-84-3(CAS DataBase Reference)
EPA Substance Registry System Methanone, (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)- (3562-84-3)

Description and Uses

Benzbromarone,a non-competitive inhibitor of xanthine oxidase,is apotent uricosuric drug used in the treatment of gout.
Benzbromarone is a benzofuran derivative chemically related to amiodarone. It increases uric acid excretion by non-specificallyinhibiting its tubular reabsorption.
lt is used in patients with venous disorders to prevent,retard,or reverse varicose degenerative changes in the vessel wall.
Benzbromarone causes diarrhea (3-4% of patients), urate and oxalate stones,urinary sand,renal colic,and allergy in a small number of patients.Liver damage, which reverses after withdrawal, has been described (SEDA-18,108).

Coronarodilatator;Uric acid transport inhibitor

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  OB1804200
HS Code  2932.99.7000
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 oral in rat: 248mg/kg

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