Home Categories API 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanineSesquihydrate
A7015158

3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanineSesquihydrate , 2mMinDMSO , 555-30-6

Synonym(s):
3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine;Methyl-L-DOPA;Methyl-DOPA sesquihydrate;MK-351

CAS NO.:555-30-6

Empirical Formula: C10H13NO4

Molecular Weight: 211.22

MDL number: MFCD00004186

EINECS: 209-089-2

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: ≥300 °C
Boiling point: 350.89°C (rough estimate)
Density  1.2545 (rough estimate)
refractive index  -14 ° (C=1, H2O)
storage temp.  Sealed in dry,2-8°C
solubility  Soluble to 75 mM in DMSO
pka 2.28±0.26(Predicted)
form  powder to crystal
color  White to Almost white
Water Solubility  10g/L(temperature not stated)
Merck  14,6055
BCS Class 3
CAS DataBase Reference 555-30-6(CAS DataBase Reference)
EPA Substance Registry System Methyldopa (555-30-6)

Description and Uses

Methyldopa is an α-methoxylated derivative of levodopa that exhibits hypotensive action by reducing overall peripheral vascular resistance and reducing heart work. Antihypertensive action of methyldopa consists of the biotransformation of methyldopa into methylnoradrenaline (methylnorepinephrine), which acts as a “pseudo neurotransmitter.” The current, universally accepted point of view is that the action of methyldopa is carried out through the CNS, where methylnorepinephrine, a powerful stimulant of α-adrenergic receptors of the medulla, inhibits the vasomotor center.

It is prescribed for arterial hypertension and hypertensive crises.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
RTECS  YP2860000
10-23
HS Code  29181990
Hazardous Substances Data 555-30-6(Hazardous Substances Data)
Toxicity LD50 oral in rabbit: 713mg/kg

RELATED PRODUCTS