Doramectin , 10mMinDMSO , 117704-25-3
Synonym(s):
25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin;Doramectin
CAS NO.：117704-25-3
Empirical Formula: C50H74O14
Molecular Weight: 899.11
MDL number: MFCD00894747
EINECS: 601-490-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 116-1190C |
| Boiling point: | 967.4±65.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | methanol: soluble |
| form | solid |
| pka | 12.42±0.70(Predicted) |
| color | white |
| InChIKey | QLFZZSKTJWDQOS-YDBLARSUSA-N |
| LogP | 4.39-4.43 at 25℃ |
Description and Uses
Doramectin[117704-25-3] is a novel avermectin with a cyclohexyl substituent on the previously inaccessible C-25 position of the molecule; the substitution was facilitated by mutational biosynthesis. The discovery of doramectin involved feeding carboxylic acids or their precursors to a fermentation of Streptomyces avermitilis that lacked branched-chain 2-oxo acid dehydrogenase activity, and then screening the resultant fermentation products for anthelmintic and ectoparasiticidal activity. Two dosage forms of doramectin have been developed for use as an endectocide on cattle, an injectable formulation for subcutaneous administration and a pouron formulation. An injectable formulation is also approved for use on pigs.
Doramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
Safety
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H361fd-H362-H410 |
| Precautionary statements | P202-P260-P263-P273-P301+P312-P308+P313 |
| Hazard Codes | T,N,Xi |
| Risk Statements | 25-50/53-36/37/38 |
| Safety Statements | 33-45-60-61-36/37-26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29419090 |
