1,2,4,5-Benzenetetraminetetrahydrochloride , 10mMinDMSO , 4506-66-5

Synonym(s):
1,2,4,5-Benzenetetraamine tetrahydrochloride;1,2,4,5-Tetraaminobenzene tetrahydrochloride;Benzene-1,2,4,5-tetramine tetrahydrochloride;Y15;1,2,4,5-Benzene tetraamine tetrahydrochloride

CAS NO.：4506-66-5

Empirical Formula: C6H11ClN4

Molecular Weight: 174.63

MDL number: MFCD00012970

EINECS: 224-822-6

PRODUCT Properties

• Melting point: ≥300 °C(lit.)
• storage temp.: room temp
• solubility: H2O: soluble20mg/mL, clear
• form: powder
• color: , faint purple to dark brown
• BRN: 3701344
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
• InChIKey: BZDGCIJWPWHAOF-UHFFFAOYSA-N

Description and Uses

FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-R.1 Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. FAK inhibitor 14 exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo. Induces regression of pancreatic tumors2 and glioblastoma3. Displays antiangiogenic activity.4

FAK Inhibitor 14 directly blocks phosphorylation of focal adhesion kinase (FAK) in a dose- and time-dependent manner and has also shown breast tumor regression in vivo. It has been suggested that targeting the Y397 site of FAK with FAK Inhibitor 14 can be effectively used in cancer therapy.

Safety

• Symbol(GHS): GHS02,GHS05
• Signal word: Danger
• Hazard statements: H225-H314
• Precautionary statements: P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P235-P405-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10