PRODUCT Properties
| Melting point: | 206-208 °C(lit.) |
| Boiling point: | 263.29°C (rough estimate) |
| Density | 0.9510 (rough estimate) |
| refractive index | 1.5220 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | 1 M HCl: soluble5%, clear to hazy, colorless to faint yellow or tan |
| form | Powder |
| pka | 10.1(at 25℃) |
| color | White to cream |
| Water Solubility | Soluble in organic solvents. Insoluble in water. |
| Merck | 14,374 |
| BRN | 2204333 |
| InChIKey | DKNWSYNQZKUICI-UHFFFAOYSA-N |
| CAS DataBase Reference | 768-94-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Tricyclo[3.3.1.13,7]decane-1-amine(768-94-5) |
| EPA Substance Registry System | Tricyclo[3.3.1.13,7]decan-1-amine (768-94-5) |
Description and Uses
Amantadine is an agent that raises the concentration of dopamine in the synaptic cleft by releasing it from neurons and suppressing the process of reuptake.
Amantadine is a primary amine derivative of adamantane. It has an effect on mycoviruses, which are RNA-containing viruses. It has a very narrow spectrum of action and is used only for treating and preventing influenza A. It is also used for treating Parkinsonism. The exact mechanism of antiviral action of amantadine is not completely understood. It is believed that it is an ion channel blocker. It has also been suggested that amantadine inhibits absorption of viral particles into the host cell, which is expressed in the breakdown of diffusion of the virus into the cell, or inhibition of the “stripping process” of the virus. The main use is for the prevention of type A2 influenza. Synonyms of this drug are simmetrel, viregit, mantadan, and others.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | YD1925000 |
| F | 10-34 |
| HS Code | 29213000 |
| Hazardous Substances Data | 768-94-5(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 900mg/kg |
