A6996858
Chlorthalidone , 10mMinDMSO , 77-36-1
Synonym(s):
2-Chloro-5(1-hydroxy-3-oxo-1- isoindolinyl) benzenesulfonamide;2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide;Chlortalidone
CAS NO.：77-36-1
Empirical Formula: C14H11ClN2O4S
Molecular Weight: 338.77
MDL number: MFCD00036257
EINECS: 201-022-5
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 265-267°C (dec.) |
| Density | 1.3356 (rough estimate) |
| refractive index | 1.5630 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | pKa 9.4 (Uncertain) |
| form | powder |
| color | white to beige |
| Water Solubility | 0.12g/L(25 ºC) |
| Stability: | Hygroscopic |
| InChIKey | JIVPVXMEBJLZRO-UHFFFAOYSA-N |
| NIST Chemistry Reference | Chlorthalidone(77-36-1) |
| EPA Substance Registry System | Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)- (77-36-1) |
Description and Uses
In terms of activity, chlorothalidone is very similar to benzothiadiazide (21.3.13) and is used as an independent drug or in combination with other antihypertensive agents for lowering arterial blood pressure, and also as an adjuvant drug for treating edema caused by cardiac insufficiency and renal irregularities, including nephrotic syndrome.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | DB1556000 |
| HS Code | 2935904000 |
| Hazardous Substances Data | 77-36-1(Hazardous Substances Data) |
| Toxicity | LD50 oral in rabbit: > 5gm/kg |
