Home Categories Organic Chemistry 3-Amino-1-propanesulfonicacid
A6992358

3-Amino-1-propanesulfonicacid , 10mMinWater , 3687-18-1

Synonym(s):
3-Amino-1-propanesulfonic acid;3APS;Acamprosate Calcium Impurity A (PhEur);Homotaurine;Tramiprosate

CAS NO.:3687-18-1

Empirical Formula: C3H9NO3S

Molecular Weight: 139.17

MDL number: MFCD00008225

EINECS: 222-977-4

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 293 °C (dec.)(lit.)
Density  1.202 (estimate)
refractive index  1.5130 (estimate)
storage temp.  2-8°C
solubility  Water (Slightly)
form  Crystalline Powder
pka 1.06±0.50(Predicted)
color  White to slightly blue
LogP -4.555
CAS DataBase Reference 3687-18-1(CAS DataBase Reference)

Description and Uses

Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.

3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  1
HS Code  29049090

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