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A6951658

Cabergoline , 10mMinDMSO , 81409-90-7

Synonym(s):
Cabergoline;Dostinex;Cabaser;1-[(6-Allylergoline-8β-yl)carbonyl]-1-[3-(dimethylamino)-propyl]-3-ethylurea;1-Ethyl-3-(3′-dimethylaminopropyl)-3-(6′-allylergoline-8′β-carbonyl)urea

CAS NO.:81409-90-7

Empirical Formula: C26H37N5O2

Molecular Weight: 451.6

MDL number: MFCD00867887

EINECS: 200-419-0

Pack Size Price Stock Quantity
1ml RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 102-104°C
Density  1.156±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: ≥10mg/mL
pka 13.05±0.46(Predicted)
form  powder
color  White to Off-White
optical activity [α]/D 61 to 68°, c = 0.5 in dichloromethane
Stability: Hygroscopic
InChIKey KORNTPPJEAJQIU-KJXAQDMKSA-N
SMILES [C@]12([H])C[C@H](CN(CC=C)[C@]1([H])CC1=CNC3C=CC=C2C1=3)C(=O)N(CCCN(C)C)C(=O)NCC |&1:0,3,9,r|
CAS DataBase Reference 81409-90-7(CAS DataBase Reference)

Description and Uses

Cabergoline is a potent, selective, and long-lasting dopamine D2 receptor agonist launched in 1993 in Belgium as a prolactin inhibitor. A single 1 mg dose of cabergoline effectively prevents puerperal lactation for up to 14 days, remarkably superior to other drugs that require a daily regimen. It has a low rate of rebound breast activity and good tolerability. Cabergoline is also in clinical trials for Parkinson's disease, breast cancer, and hyperprolactinaemia.

receptor stimulant

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37
WGK Germany  3
RTECS  KE6167600
HS Code  2939690000
Toxicity Sol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: >400 mg/kg (Brambilla)

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