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A6932412

Picamilon , >98.0% , 34562-97-5

CAS NO.:34562-97-5

Empirical Formula: C10H12N2O3

Molecular Weight: 208.21

MDL number: MFCD08272808

EINECS: 1308068-626-2

Pack Size Price Stock Quantity
250MG RMB31.20 In Stock
1G RMB63.20 In Stock
5G RMB239.20 In Stock
25g RMB799.20 In Stock
100g RMB1599.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 211.0 to 215.0 °C
Boiling point: 522.4±30.0 °C(Predicted)
Density  1.245
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO (Slightly, Heated), Methanol (Slightly)
form  Solid
pka 4.60±0.10(Predicted)
color  White to Off-White
InChI InChI=1S/C10H12N2O3/c13-9(14)4-2-6-12-10(15)8-3-1-5-11-7-8/h1,3,5,7H,2,4,6H2,(H,12,15)(H,13,14)
InChIKey NAJVRARAUNYNDX-UHFFFAOYSA-N
SMILES C(O)(=O)CCCNC(C1=CC=CN=C1)=O
CAS DataBase Reference 34562-97-5(CAS DataBase Reference)

Description and Uses

Picamilon: an analogue of the neurotransmitter γ-aminobutyric acid (GABA)
Picamilon is a derivative of γ-aminobutyric acid (GABA) and nicotinic acid developed in 1970 by the All-Union Vitamin Research Institute to increase central nervous system (CNS) levels of γ-aminobutyric acid (GABA). Drugs that can mimic or increase GABA activity in the brain have the potential to provide anti-anxiety and anti-convulsive effects. GABA itself, when consumed orally, does not cross the blood-brain barrier. Much research has, therefore, been devoted to developing orally active agents that have GABA-like effects. Both gabapentin (a GABA analogue) and picamilon were designed to be orally administered drugs that cross the blood-brain barrier and provide inhibitory CNS effects. Picamilon, prescribed in dosages from 50 mg to 200 mg, can cross the blood-brain barrier in animal models and, once in the CNS, is hydrolyzed into GABA and nicotinic acid. The released GABA could potentially have inhibitory properties, including anti-anxiety and anti-convulsant effects. Nicotinic acid would also be released, potentially leading to dilation of CNS blood vessels. The FDA has never approved picamilon for use in the USA, but picamilon is used in Russia to treat various neurological conditions[1].

Nicotinoyl-γ-aminobutyric Acid is a pro-drug of γ-Aminobutyric Acid (A602920). Studies show that Nicotinoyl-γ-aminobutyric Acid is involved in the regulation of the processes in the brain of streptozotocin-induced diabetic rats.

Safety

Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2933599590

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