<i>p</i>-Acetotoluidine , >98.0%(GC) , 103-89-9

Synonym(s):
p-Acetotoluidide;4′-Methylacetanilide;N-p-Tolylacetamide, Acetic acid p-toluidide, 4-Acetamidotoluene

CAS NO.：103-89-9

Empirical Formula: C9H11NO

Molecular Weight: 149.19

MDL number: MFCD00008677

EINECS: 203-155-4

PRODUCT Properties

• Melting point: 149-151 °C(lit.)
• Boiling point: 307 °C(lit.)
• Density: 1.21
• vapor density: 5.14
• refractive index: 1.5279 (estimate)
• Flash point: 168 °C
• storage temp.: Store below +30°C.
• solubility: 1.2g/l (experimental)
• form: Crystals or Crystalline Powder
• pka: 15.13±0.70(Predicted)
• color: Beige to light brown
• Water Solubility: 1 g/L (25 ºC)
• Merck: 14,74
• BRN: 607036
• InChIKey: YICAMJWHIUMFDI-UHFFFAOYSA-N
• CAS DataBase Reference: 103-89-9(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(4-methylphenyl)-(103-89-9)
• EPA Substance Registry System: p-Acetotoluidide (103-89-9)

Description and Uses

p-Acetotoluidide is an off-white to brown flake, odourless, solid or crystalline powder (pure form), which is soluble in hot water, alcohol, ether, chloroform, acetone, glycerol, and benzene. It is combustible and undergoes self-ignition (at 5450°C) but is otherwise stable under most conditions. p-Acetanilide on decomposition releases carbon monoxide, oxides of nitrogen, carbon dioxide, and toxic fumes. p-Acetanilide is used as an inhibitor of peroxides and stabiliser for cellulose ester varnishes. It is used as an intermediate for the synthesis of rubber accelerators, dyes and dye intermediate, and camphor. It is also used as a precursor in penicillin synthesis and other pharmaceuticals including painkillers and intermediates. Phenylacetamide structure shows analgesic and antipyretic effects. But acetanilide is not used directly for this application due to causing methemoglobinemia (the presence of excessive methemoglobin which does not function reversibly as an oxygen carrier in the blood).

4′-Methylacetanilide was used in the synthesis of stable crystalline phosphorus ylides.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: AN2930000
• TSCA: Yes
• HS Code: 29242995
• Toxicity: LD50 orl-rat: 2640 mg/kg MarJV# 29MAR77