Pyrilamine Maleate Salt , 98% , 59-33-6
Synonym(s):
Mepyramine maleate salt;N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt;Pyrilamine maleate salt
CAS NO.:59-33-6
Empirical Formula: C21H27N3O5
Molecular Weight: 401.46
MDL number: MFCD00069333
EINECS: 200-422-7
Pack Size | Price | Stock | Quantity |
1G | RMB55.20 | In Stock |
|
5g | RMB168.80 | In Stock |
|
25G | RMB551.20 | In Stock |
|
100G | RMB1983.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 101-103°C |
storage temp. | 2-8°C |
solubility | Very soluble in water, freely soluble in ethanol (96 per cent). |
form | Solid |
color | White |
Water Solubility | Soluble in water at 100mg/ml |
λmax | 310nm(EtOH)(lit.) |
Merck | 14,7984 |
Stability: | Stability Combustible. Incompatible with strong oxidizing agents. |
LogP | 2.751 (est) |
CAS DataBase Reference | 59-33-6(CAS DataBase Reference) |
EPA Substance Registry System | Pyrilamine maleate (59-33-6) |
Description and Uses
Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is reported to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC50 value of -7.94.
Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36/37 |
WGK Germany | 3 |
RTECS | UT1225000 |
TSCA | Yes |
HS Code | 2933399090 |
Toxicity | LD50 orally in mice: 338 mg/kg (Hunziker) |