Pyrilamine Maleate Salt , 98% , 59-33-6

Synonym(s):
Mepyramine maleate salt;N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt;Pyrilamine maleate salt

CAS NO.：59-33-6

Empirical Formula: C21H27N3O5

Molecular Weight: 401.46

MDL number: MFCD00069333

EINECS: 200-422-7

PRODUCT Properties

• Melting point: 101-103°C
• storage temp.: 2-8°C
• solubility: Very soluble in water, freely soluble in ethanol (96 per cent).
• form: Solid
• color: White
• Water Solubility: Soluble in water at 100mg/ml
• λmax: 310nm(EtOH)(lit.)
• Merck: 14,7984
• Stability: Stability Combustible. Incompatible with strong oxidizing agents.
• LogP: 2.751 (est)

Description and Uses

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H₁ receptor. It is reported to bind with high affinity to a G_q/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H₁ receptor that interferes with the G_q/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC₅₀ value of -7.94.

Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• RTECS: UT1225000
• TSCA: Yes
• HS Code: 2933399090
• Toxicity: LD50 orally in mice: 338 mg/kg (Hunziker)