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A6811612

Pidotimod , ≥98% , 121808-62-6

Synonym(s):
(4R)-3-(5-Oxo-L-prolyl)-1,3-thiazolidine-4-carboxylic acid;(R)-3-((S)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid;(R)-3-[(S)-(5-Oxo-2-pyrrolidinyl) carbonyl]-thiazolidine-4-carboxylic acid;3-L-Pyroglutamyl-L-thiaziolidine-4carboxylic acid;PGT/1A

CAS NO.:121808-62-6

Empirical Formula: C9H12N2O4S

Molecular Weight: 244.27

MDL number: MFCD00867583

EINECS: 2017-001-1

Pack Size Price Stock Quantity
5G RMB312.80 In Stock
25G RMB930.40 In Stock
100G RMB2076.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 194-198°C (dec.)
alpha  D25 -150° (c = 2 in 5N HCl)
Boiling point: 663.0±55.0 °C(Predicted)
Density  1.53
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  DMSO (Slightly, Heated), Methanol (Slightly, Heated), 5N HCl (Slightly)
form  powder
pka 3.03(at 25℃)
color  white to beige
optical activity [α]/D -135 to -155°, c = 1 in 6 M HCl
Merck  14,7419
InChI InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
InChIKey UUTKICFRNVKFRG-WDSKDSINSA-N
SMILES S1C[C@@H](C(O)=O)N(C([C@@H]2CCC(=O)N2)=O)C1
CAS DataBase Reference 121808-62-6(CAS DataBase Reference)

Description and Uses

Pidotimod, a dipeptide immunomodulating agent, has been introduced as immunostimulant therapy in patients with cell-mediated immunosuppression during respiratory or urinary tract infections. Its mode of action on the immune system is by activation of T-lymphocytes via interleukin (IL)-2 stimulation and macrophages via activation of superoxide dismutase and chemotaxis. In mice, treatment with pidotimod causes significant increase in the natural killer cell activity that may play an important role in immunosurveillance against tumors and in physiological homeostasis. Pidotimod can reverse the immunosuppression caused by surgical stress and has antiinflammatory, antioxidant, and antiaging properties. It has also been reported to provide protection from bacterial infections in mice.

immune stimulant

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
RTECS  XJ5426675
HS Code  2934.10.9000
Toxicity LD50 in mice and rats (mg/kg): >4000 i.v.; >4000 i.m.; >8000 i.p.; >8000 orally (Coppi)

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