Pyrazinamide , ≥98% , 98-96-4

Synonym(s):
2-Pyrazinecarboxamide;Pyrazinamide;Pyrazine-2-carboxamide;Pyrazinecarboxamide;Pyrazinoic acid amide

CAS NO.：98-96-4

Empirical Formula: C5H5N3O

Molecular Weight: 123.11

MDL number: MFCD00006132

EINECS: 202-717-6

PRODUCT Properties

• Melting point: 189-191 °C (lit.)
• Boiling point: 229.19°C (rough estimate)
• Density: 1.3260 (rough estimate)
• refractive index: 1.5900 (estimate)
• Flash point: >110°(230°F)
• storage temp.: 2-8°C
• solubility: H2O: soluble50mg/mL
• form: Crystalline Powder or Needles
• pka: 0.5(at 25℃)
• color: White
• PH: 7 (H2O)
• Water Solubility: 15 mg/mL
• Merck: 14,7956
• BRN: 112306
• BCS Class: 1,3
• LogP: -0.600

Description and Uses

Pyrazinamide was synthesized in 1952, and it is the nitrogen-analog of nicotinamide. It exhibits hepatotoxicity. Synonyms of this drug are dexambutol, miambutol, esnbutol, ebutol, and others.

Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P271-P280
• Hazard Codes: F,C
• Risk Statements: 11-34
• Safety Statements: 22-24/25-45-36/37/39-26-16
• WGK Germany: 3
• RTECS: UQ2275000
• TSCA: Yes
• HS Code: 29339990
• Toxicity: LD50 intraperitoneal in mouse: 1680mg/kg