PFI-1 , ≥98% , 1403764-72-6

Synonym(s):
2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-bezenesulfonamide;PF-06405761

CAS NO.：1403764-72-6

Empirical Formula: C16H17N3O4S

Molecular Weight: 347.39

MDL number: MFCD22580416

Pack Size	Price	Stock	Quantity
1MG	RMB95.20	In Stock
5MG	RMB319.20	In Stock
10mg	RMB431.20	In Stock
25MG	RMB975.20	In Stock
50mg	RMB1727.20	In Stock
100MG	RMB2678.40	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

storage temp.	Sealed in dry,2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
color	white to beige

Description and Uses

PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells.

PFI-1 is used as a selective protein interaction inhibitor targetting BET bromodomains, used as regulators required for efficient expression of several growth promoting and anti-apoptotic genes.