A6787012
Pelitinib , ≥98% , 257933-82-7
Synonym(s):
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;EKB 569;EKB-569;WAY-EKB-569
CAS NO.：257933-82-7
Empirical Formula: C24H23ClFN5O2
Molecular Weight: 467.92
MDL number: MFCD09837868
EINECS: 803-625-4
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB551.20 | In Stock |
|
| 25MG | RMB714.40 | In Stock |
|
| 100MG | RMB2158.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 173-178°C |
| Boiling point: | 655.5±55.0 °C(Predicted) |
| Density | 1.34 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| pka | 12.23±0.43(Predicted) |
| color | white to beige |
Description and Uses
Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM). It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).
Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.
