PF-477736 , 98% , 952021-60-2
Synonym(s):
(2R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide;PF-00477736
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB684.80 | In Stock |
|
| 25MG | RMB2559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.56 |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | 11.79±0.20(Predicted) |
| color | yellow |
| InChIKey | NDEXUOWTGYUVGA-LJQANCHMSA-N |
Description and Uses
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.[Cayman Chemical]
Safety
| WGK Germany | 3 |
