Parthenolide , Analysis of standard products, ≥98% , 20554-84-1

Synonym(s):
Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem

CAS NO.：20554-84-1

Empirical Formula: C15H20O3

Molecular Weight: 248.32

MDL number: MFCD00134592

EINECS: 692-532-0

PRODUCT Properties

• Melting point: 115-116 °C (lit.)
• alpha: D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
• Boiling point: 394.1±42.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)
• form: White solid
• color: White
• Merck: 14,7048
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChI: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
• InChIKey: KTEXNACQROZXEV-PVLRGYAZSA-N
• SMILES: O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10|
• LogP: 2.424 (est)

Description and Uses

Parthenolide is an allergen in feverfew (Tanacetum parthenarium).

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317
• Precautionary statements: P280-P302+P352
• Hazard Codes: Xi,C,F
• Risk Statements: 11-34
• Safety Statements: 22-24/25-45-36/37/39-26-16
• WGK Germany: 3
• RTECS: LY4220000
• HS Code: 29322090