Pyrimethamine , Analysis standard , 58-14-0

Synonym(s):
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;Pyrimethamine

Update time: 2022-07-08

Melting point:	233-234°C
Boiling point:	393.35°C (rough estimate)
Density	1.2171 (rough estimate)
refractive index	1.6110 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanol R and 3 volumes of methylene chloride R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).
form	Solid
pka	pKa 7(t=20.0) (Uncertain)
color	White to Off-White
Water Solubility	<0.01 g/100 mL at 21 ºC
λmax	276nm(lit.)
Merck	14,7985
BRN	219864
BCS Class	2 (CLogP), 4 (LogP),3
Stability:	Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	58-14-0(CAS DataBase Reference)
IARC	3 (Vol. 13, Sup 7) 1987
NIST Chemistry Reference	Pyrimethamine(58-14-0)
EPA Substance Registry System	Pyrimethamine (58-14-0)

Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial