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A6727112

Pyrimethamine , Analysis standard , 58-14-0

Synonym(s):
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;Pyrimethamine

CAS NO.:58-14-0

Empirical Formula: C12H13ClN4

Molecular Weight: 248.71

MDL number: MFCD00057350

EINECS: 200-364-2

Pack Size Price Stock Quantity
250MG RMB79.20 In Stock
5G RMB142.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 233-234°C
Boiling point: 393.35°C (rough estimate)
Density  1.2171 (rough estimate)
refractive index  1.6110 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanol R and 3 volumes of methylene chloride R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).
form  Solid
pka pKa 7(t=20.0) (Uncertain)
color  White to Off-White
Water Solubility  <0.01 g/100 mL at 21 ºC
λmax 276nm(lit.)
Merck  14,7985
BRN  219864
BCS Class 2 (CLogP), 4 (LogP),3
Stability: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.

Description and Uses

Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
RIDADR  3249
WGK Germany  3
RTECS  UV8140000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29335990
Toxicity LD50 oral in rat: 440mg/kg

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