Home Categories Chemical pesticides Propargyl bromide
A6667512

Propargyl bromide , 98%, containing 0.3%MGO stabilizer , 106-96-7

Synonym(s):
3-Bromo-1-propyne

CAS NO.:106-96-7

Empirical Formula: C3H3Br

Molecular Weight: 118.96

MDL number: MFCD00000241

EINECS: 203-447-1

Update time: 2022-07-08

PRODUCT Properties

Melting point: -61°C
Boiling point: 97 °C
Density  1.38 g/mL at 20 °C
refractive index  n20/D 1.494
Flash point: 65 °F
storage temp.  2-8°C
solubility  Chloroform, Methanol (Slightly)
form  Liquid
color  Colorless - Yellow
Water Solubility  Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.
Sensitive  Light Sensitive
BRN  605309
Exposure limits ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
InChIKey YORCIIVHUBAYBQ-UHFFFAOYSA-N

Description and Uses

Propargyl bromide is a Shock sensitive liquid, lachrymator. Supplied as an 80% solution in toluene stabilized with magnesium oxide. Alternative formulations are currently under development.

Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

Safety

Symbol(GHS) 
GHS02,GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301-H304-H314-H335-H373
Precautionary statements  P210-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  F,T,C
Risk Statements  60-61-20/21-25-63-36/37/38-11-67-65-48/20
Safety Statements  53-16-36/37/39-45-37/39-28A-26-62-36/37
RIDADR  UN 2345 3/PG 2
WGK Germany  3
RTECS  UK4375000
8
Hazard Note  Highly Flammable/Toxic/Corrosive
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29033990

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