Home Categories API 6-Propyl-2-thiouracil
A6662912

6-Propyl-2-thiouracil , 98% , 51-52-5

Synonym(s):
2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone;4-Hydroxy-2-mercapto-6-propylpyrimidine;4-Propyl-2-thiouracil;6-Propyl-2-thiouracil

CAS NO.:51-52-5

Empirical Formula: C7H10N2OS

Molecular Weight: 170.23

MDL number: MFCD00006041

EINECS: 200-103-2

Pack Size Price Stock Quantity
25G RMB82.40 In Stock
100G RMB255.20 In Stock
500G RMB896.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 218-220 °C (lit.)
Density  1.1880 (rough estimate)
refractive index  1.5960 (estimate)
Flash point: 300 °C
storage temp.  2-8°C
solubility  1.1g/l
form  Solid
pka pKa 7.8; 8.3 (Uncertain)
color  White
PH 6-7.5 (5g/l, H2O, 20℃)(slurry)
Water Solubility  1.1 g/L
Merck  14,7869
BRN  130039
BCS Class 3
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive.

Description and Uses

Propylthiouracil (PTU) is a thioamide antithyroid agent. It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3''-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds. Formulations containing propylthiouracil have been used in the treatment of Graves'' disease and hyperthyroidism.

Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H351
Precautionary statements  P280-P301+P312+P330
Hazard Codes  Xn,Xi
Risk Statements  22-40
Safety Statements  36/37-45
WGK Germany  3
RTECS  YR1400000
Hazard Note  Harmful/Irritant
HS Code  29335995
Toxicity LD50 orally in Rabbit: 1250 mg/kg

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