D-Pyroglutamic acid , 98% , 4042-36-8

Synonym(s):
D-5-Oxo-2-pyrrolidinecarboxylic acid;D-Pyroglutamic acid

CAS NO.：4042-36-8

Empirical Formula: C5H7NO3

Molecular Weight: 129.11

MDL number: MFCD00066212

EINECS: 223-735-0

PRODUCT Properties

• Melting point: 155-162 °C
• alpha: 27.5 º (c=10,1N NaOH)
• Boiling point: 239.15°C (rough estimate)
• Density: 1.3816 (rough estimate)
• refractive index: 10 ° (C=5, H2O)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Dimethylformamide, DMSO (Slightly), Methanol (Slightly), Water
• form: Solid
• pka: 3.48±0.20(Predicted)
• color: Off-White to Light Beige
• optical activity: [α]22/D +10°, c = 1.5 in H2O
• Water Solubility: soluble
• Merck: 14,8001
• BRN: 82133
• InChIKey: ODHCTXKNWHHXJC-GSVOUGTGSA-N
• CAS DataBase Reference: 4042-36-8(CAS DataBase Reference)

Description and Uses

D-Pyroglutamic acid, also known as 5-oxo-D-proline, is a metabolite of D-glutamate. It is formed from D-glutamate by D-glutamate cyclase. The levels of D-pyroglutamic acid are increased in the urine of patients with nascent metabolic syndrome and the plasma of patients with end-stage renal disease.

Serves as a building block in the synthesis of diphthamide.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HS Code: 29339900