(R)-(-)-Phenylephrine hydrochloride , 99% , 61-76-7

Synonym(s):
(R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride;(R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride;(R)-(−)-Phenylephrine hydrochloride;PHE

CAS NO.：61-76-7

Empirical Formula: C9H13NO2.ClH

Molecular Weight: 203.67

MDL number: MFCD00012605

EINECS: 200-517-3

PRODUCT Properties

• Melting point: 143-145 °C(lit.)
• alpha: -47 º (c=2, H2O)
• refractive index: -45.5 ° (C=1, H2O)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: Freely soluble in water and in ethanol (96 per cent).
• form: Crystalline Powder
• pka: pK1 8.77; pK2 9.84(at 25℃)
• color: White to almost white
• PH: pH (10g/L, 25℃) : 4.5～5.5
• Water Solubility: >=10 g/100 mL at 21 ºC
• Merck: 14,7286
• BRN: 4158948
• Stability: Hygroscopic
• LogP: -0.310

Description and Uses

R-(-)-Phenylephrine is an adrenergic α_1A receptor agonist (K_i = 1.4 μM) that demonstrates selectivity against the α_1B and α_1C receptor subtypes (K_is = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α₁ receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine . This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.

(R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H317
• Precautionary statements: P261-P264-P270-P280-P301+P312-P302+P352
• Hazard Codes: Xn,T,F
• Risk Statements: 22-36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 26-36-37/39-45-36/37-16-7
• RIDADR: 3249
• WGK Germany: 3
• RTECS: DO7525000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29225090
• Toxicity: LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner)