Home Categories Chemical Reagents Phenazine methosulfate
A6655812

Phenazine methosulfate , 98% , 299-11-6

Synonym(s):
N-Methylphenazonium methyl sulfate;5-Methylphenazinium methyl sulfate;PMS

CAS NO.:299-11-6

Empirical Formula: C14H14N2O4S

Molecular Weight: 306.34

MDL number: MFCD00011923

EINECS: 206-072-1

Pack Size Price Stock Quantity
1G RMB58.40 In Stock
5G RMB179.20 In Stock
25G RMB677.60 In Stock
100G RMB2159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 158-160 °C (dec.)(lit.)
Density  1.3395 (rough estimate)
refractive index  1.6930 (estimate)
storage temp.  -20°C
solubility  H2O: 0.2 g/mL at 20 °C, clear, deep orange
form  Crystalline Powder
color  Dark yellow to brown or khaki
Water Solubility  soluble in water (approximately 200 mg/ml).
Sensitive  Light Sensitive
Merck  14,6109
BRN  3898869
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 299-11-6(CAS DataBase Reference)
EPA Substance Registry System Phenazinium, 5-methyl-, methyl sulfate (299-11-6)

Description and Uses

Phenazine is a free radical generator. It has been used as an electron transfer reactant in cell viability assays. Phenazine (10 μM) induces ssDNA break formation in the presence of the reducing agent NADPH in a cell-free plasmid cleavage assay when used at a concentration of 10 μM. It induces oxidative DNA damage in an alkaline comet assay and apoptosis in A375 melanoma cells when used at a concentration of 10 μM. Phenazine (20 nM) oxidizes cysteine-containing proteins in HepG2 cells.

Phenazine Methosulfate is used in tyrosine transaminase test and for enzymic determination of ethanol in blood by the colorimetric micromethod. Used with ascorbic acid to determine nitric oxide reductase activity. Since the reduced PMS is easily oxidized by oxygen, it is used in assays as an electron carrier between enzymes and oxygen, cytochrome c, indophenols, or tetrazolium salts. The reduced PMS is used as an electron donor to reduce cytochrome c or in photosynthetic experiments. Usage of PMS for detection of specific dehydrogenases has been reported.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn,T
Risk Statements  36/37/38-68-46
Safety Statements  26-36/37/39-53-45
RIDADR  2811
WGK Germany  3
RTECS  SG1645000
8
TSCA  Yes
HS Code  29339900

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