Polymyxin B sulfate , USP level, ≥6,000USPUNITS/MG , 1405-20-5

Synonym(s):
Polymyxin B sulfate;Polymixin B;Bacillus Cereus;Polymixin;Aerosporin

CAS NO.：1405-20-5

Empirical Formula: C56H100N16O17S

Molecular Weight: 1301.56

MDL number: MFCD30489731

EINECS: 215-774-7

PRODUCT Properties

• Melting point: 217-220°C (dec.)
• storage temp.: 2-8°C
• solubility: H₂O: 50 mg/mL
• form: powder
• pka: pKa 8.9 (Uncertain)
• color: colorless or slightly yellow
• PH: pH (10g/L, 25℃) : 4.5～7.0
• optical activity: [α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
• Water Solubility: Soluble in water at 50mg/ml/n
• Merck: 14,7573
• Stability: Hygroscopic
• InChIKey: HFMDLUQUEXNBOP-UHFFFAOYSA-N
• LogP: -6.361 (est)
• CAS DataBase Reference: 1405-20-5(CAS DataBase Reference)
• EPA Substance Registry System: Polymixin B sulfate (1405-20-5)

Description and Uses

The polymyxins are cationic peptides originally isolated from B. polymyxa. They bind and kill Gram-negative bacteria. The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B₁ to B₄, with polymyxin B₁ and B₂ being the two major components. Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.

Polymyxin B sulfate is used as topical antibiotic agent, often used in combination with neomycin; products include ointments, creams, eye, and ear drops.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 22-24/25
• RIDADR: 3249
• WGK Germany: 3
• RTECS: TR1150000
• F: 3-8-10
• HS Code: 2941 90 00
• HazardClass: 6.1(b)
• PackingGroup: III
• Toxicity: dog,LDLo,intracrebral,320ug/kg (0.32mg/kg),BEHAVIORAL: COMA,British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 552, 1964.