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A6638512

Pentylenetetrazole , 98% , 54-95-5

Synonym(s):
α,β-Cyclopentamethylenetetrazole;1,5-Pentamethylenetetrazole;6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine;Metrazole

CAS NO.:54-95-5

Empirical Formula: C6H10N4

Molecular Weight: 138.17

MDL number: MFCD00005939

EINECS: 200-219-3

Pack Size Price Stock Quantity
1G RMB55.20 In Stock
5G RMB191.20 In Stock
25G RMB751.20 In Stock
100g RMB1583.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 59-61 °C (lit.)
Boiling point: 194 °C/12 mmHg (lit.)
Density  1.0617 (rough estimate)
refractive index  1.4910 (estimate)
Flash point: 194°C/12mm
storage temp.  -20°C
solubility  ≥15.38 mg/mL in EtOH; ≥6.3 mg/mL in DMSO; ≥83.2 mg/mL in H2O
form  solid
pka 1.25±0.20(Predicted)
color  White, crystalline powder
Sensitive  Hygroscopic
Merck  14,7141
BRN  135492
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey CWRVKFFCRWGWCS-UHFFFAOYSA-N
CAS DataBase Reference 54-95-5(CAS DataBase Reference)
NIST Chemistry Reference Pentylenetetrazol(54-95-5)
EPA Substance Registry System Pentetrazol (54-95-5)

Description and Uses

Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAA receptor.

Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P301+P310+P330-P302+P352-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38-23/24/25
Safety Statements  26-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  XF8225000
TSCA  Yes
HazardClass  6.1
PackingGroup  II
Toxicity LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal)

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