Home Categories Analytical Chemistry 9-Oxo-10(9H)-acridineacetic acid
A6550612

9-Oxo-10(9H)-acridineacetic acid , >98.0%(HPLC) , 38609-97-1

Synonym(s):
(9,10-Dihydro-9-oxo-10-acridinyl)acetic acid;10-(Carboxymethyl)-9(10H)acridone

CAS NO.:38609-97-1

Empirical Formula: C15H11NO3

Molecular Weight: 253.25

MDL number: MFCD00157050

EINECS: 634-833-1

Pack Size Price Stock Quantity
1G RMB70.40 In Stock
5G RMB200.80 In Stock
25G RMB472.00 In Stock
100g RMB1839.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: ~289 °C (dec.)
Boiling point: 486.6±34.0 °C(Predicted)
Density  1.362
storage temp.  Sealed in dry,Room Temperature
solubility  Aqueous Base (Slightly), DMSO (Slightly)
form  Solid
pka 3.69±0.10(Predicted)
color  Pale Yellow to Light Yellow
λmax 410nm(H2O)(lit.)
BRN  227508
InChI InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)
InChIKey UOMKBIIXHQIERR-UHFFFAOYSA-N
SMILES C1=C2C(N(CC(O)=O)C3=C(C2=O)C=CC=C3)=CC=C1

Description and Uses

9-Oxo-10(9H)-acridineacetic acid , also known as Cridanimod or XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.

9-Oxo-10(9H)-acridineacetic acid is a reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC and it is also a building block in pharmaceutics.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
RTECS  AR7190000
HS Code  2933.99.8290

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