Ornidazole , ≥98.0% , 16773-42-5
Synonym(s):
1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole
CAS NO.：16773-42-5
Empirical Formula: C7H10ClN3O3
Molecular Weight: 219.63
MDL number: MFCD00057960
EINECS: 240-826-0
| Pack Size | Price | Stock | Quantity |
| 5G | RMB24.00 | In Stock |
|
| 25G | RMB39.20 | In Stock |
|
| 100G | RMB105.60 | In Stock |
|
| 500g | RMB476.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 85-90°C |
| Boiling point: | 443.2±40.0 °C(Predicted) |
| Density | 1.6545 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in ethanol at 50mg/ml |
| pka | 2.4 ± 0.1(at 25℃) |
| form | Solid |
| color | Crystals from toluene |
| λmax | 276nm(H2SO4 aq.)(lit.) |
| Merck | 14,6872 |
| InChIKey | IPWKIXLWTCNBKN-UHFFFAOYSA-N |
| CAS DataBase Reference | 16773-42-5(CAS DataBase Reference) |
Description and Uses
Ornidazole is an orally bioavailable 5-nitroimidazole derivative with antibacterial and antiprotozoal activities. Ornidazole inhibits the growth of clinical isolates of B. fragilis (MICs = 0.5-5 μM) and various anaerobic bacteria when used at concentrations ranging from less than 0.1 to 3.2 μg/ml. It also inhibits the growth of Giardia isolates (IC50s = 0.01-0.47 μg/ml). Oral administration of ornidazole reduces T. vaginalis and T. foetus infection in mice and E. histolytica infection in rats with curative dose (CD50) values of 37, 3, and 10 mg/kg, respectively. Ornidazole (400 mg/kg per day) induces infertility in male rats within 7 days and inhibits spermatozoa binding to rat oocyte zona pellucida.
Ornidazole is a drug that cures some protozoan infections. It has been investigated for use in Crohn's disease after bowel resection. It is indicated in treatment of mixed amoebiasis, mixed amoebic dysentery, mixed giardiasis, trichomoniasis, bacterial vaginosis, Sexually transmitted diseases, infections of gynaecology, lower respiratory tract infections, ENT, surgical and dental infections.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312a-P330-P501a |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | NI5460000 |
| HS Code | 2933.29.4300 |
| HazardClass | IRRITANT |
| Toxicity | LD50 in rats, mice (mg/kg): 1780, 1420 orally (Grunberg); LD50 in mice (mg/kg): >2000 orally, >2000 i.p. (Hoffer, Grunberg) |
