Scutellarein , ≥98%(HPLC) , 529-53-3

Synonym(s):
4′,5,6,7-Tetrahydroxyflavone;6-Hydroxyapigenin

CAS NO.：529-53-3

Empirical Formula: C15H10O6

Molecular Weight: 286.24

MDL number: MFCD00017692

EINECS: 1806241-263-5

PRODUCT Properties

• Melting point: 330°C
• Boiling point: 642.9±55.0 °C(Predicted)
• Density: 1.654±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO: soluble1mg/mL, clear, greenish-yellow
• pka: 6.34±0.40(Predicted)
• form: powder
• color: yellow
• InChIKey: JVXZRQGOGOXCEC-UHFFFAOYSA-N
• LogP: 2.540 (est)

Description and Uses

Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC₅₀s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM. In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.

Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.

Safety

• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29329990