Home Categories Inorganic chemistry Hydroxylammoniumchloride
A6233851

Hydroxylammoniumchloride , 99% , 5470-11-1

Synonym(s):
Hydroxylamine hydrochloride;Hydroxylammonium chloride;Hydroxylammonium Chloride, Hydroxyl Ammonium Chloride

CAS NO.:5470-11-1

Empirical Formula: NH2OH·HCl

Molecular Weight: 69.49

MDL number: MFCD00051089

EINECS: 226-798-2

Pack Size Price Stock Quantity
100g RMB39.20 In Stock
500g RMB86.40 In Stock
2.5kg RMB332.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 155-157 °C (dec.)(lit.)
Density  1.67 g/mL at 25 °C(lit.)
vapor pressure  0.054 Pa (50 °C)
storage temp.  Store at +15°C to +25°C.
solubility  470g/l
form  Liquid
color  White to off-white
PH 2.5-3.5 (25℃, 50mg/mL in H2O)
Water Solubility  560 g/L (20 ºC)
Sensitive  Hygroscopic
Merck  14,4828
BRN  3539763
Stability: Substances to be avoided include strong oxidizing agents. Heating above 115 C may cause explosion; do not store above 65C. Moisture and air sensitive.
InChIKey WTDHULULXKLSOZ-UHFFFAOYSA-N
LogP -0.810 (est)
CAS DataBase Reference 5470-11-1(CAS DataBase Reference)
EPA Substance Registry System Hydroxylamine hydrochloride (5470-11-1)

Description and Uses

Hydroxylamine hydrochloride is a reducing agent that is routinely used for the deacetylation of SATA to form free sulfhydryls (Figure 1), for cleavage of protein cross‐linkers that contain carbonyl groups (i.e. EGS) and for mutagenesis of plasmid DNA.

Hydroxylamine converts aldehydes and ketones (carbonyls) to their oxime derivative in weak bases, therefore cross‐linkers and other compounds with carbonyl groups are cleavable with Hydroxylamine hydrochloride.
SATA and SATP are modification reagents that add a sulfhydryl group to primary amines on biomolecules. The initial modification results in the addition of an acetyl‐protected sulfur enabling storage of the biomolecule. To generate a free sulfhydryl the biomolecule is treated with hydroxylamine to remove the protecting acetyl group (see figure).
EGS and sulfo‐EGS are homobifunctional, succinimidyl ester, amine reactive crosslinkers that are resistant to cleavage by denaturants used in SDS‐PAGE conditions, but may be cleaved with hydroxylamine.

Hydroxylamine hydrochloride is a monomoamine oxidase inhibitor. It is used to prepare oximes and hydroxmic acids in organic synthesis. It acts as a copolymerization inhibitor. It can be used to remove bromine and polybromide from a solution during extraction of lignin from lignocellulosic biomass. It is key starting material for the preparation of pharmaceuticals and agrochemicals. It plays a vital role in rubber and plastic industries as an antioxidant, a vulcanization accelerator and a radical scavenger. It is also used as a color stabilizer and emulsion additive in color films.

Safety

Symbol(GHS) 
GHS05,GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H290-H302+H312-H315-H317-H319-H351-H373-H400
Precautionary statements  P273-P280-P301+P312-P302+P352+P312-P305+P351+P338-P308+P313
Hazard Codes  Xn,N,E
Risk Statements  22-36/38-43-48/22-50-40-21/22-2
Safety Statements  22-24-37-61-36/37
RIDADR  UN 2923 8/PG 2
WGK Germany  3
RTECS  NC3675000
21
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  28251000
Toxicity LD50 orally in mice: 408 mg/kg (Riemann)

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