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A6226912

Niclosamide , 98% , 50-65-7

Synonym(s):
2′,5-Dichloro-4′-nitrosalicylanilide;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide, mTOR Inhibitor IX, Autophagy Inducer III, STAT3 Inhibitor XV, Wnt Pathway Inhibitor XIII;Niclosamide - CAS 50-65-7 - Calbiochem

CAS NO.:50-65-7

Empirical Formula: C13H8Cl2N2O4

Molecular Weight: 327.12

MDL number: MFCD00057597

EINECS: 200-056-8

Pack Size Price Stock Quantity
50G RMB183.20 In Stock
250G RMB551.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 225-230°
Boiling point: 424.5±45.0 °C(Predicted)
Density  1.6646 (rough estimate)
refractive index  1.6200 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  acetone: methanol: soluble50mg/mL (methanol:acetone (1:1))
form  Pale yellow solid
pka 7.45±0.43(Predicted)
color  Yellow
Water Solubility  13.32mg/L(25 ºC)
BRN  2820605
BCS Class 4
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Description and Uses

Niclosamide (50-65-7) reversibly inhibits mTORC1 signaling and stimulates autophagy.1 Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Niclosamide inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3.2

An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.

Safety

Symbol(GHS) 
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273-P391-P501
Risk Statements  50
Safety Statements  29
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  VN8400000
HS Code  29242990
Toxicity LD50 oral in rat: 2500mg/kg

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