Nicardipine hydrochloride , ≥98% , 54527-84-3

Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methyl(phenylmethyl)amino]ethyl ester hydrochloride;Nicardipine hydrochloride;YC-93

CAS NO.：54527-84-3

Empirical Formula: C26H30ClN3O6

Molecular Weight: 515.99

MDL number: MFCD00057327

EINECS: 259-198-4

PRODUCT Properties

• Melting point: 176-1780C
• storage temp.: 2-8°C
• solubility: DMSO: ~1 mg/mL
• form: powder
• color: yellow
• Merck: 14,6495
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month.
• InChIKey: AIKVCUNQWYTVTO-UHFFFAOYSA-N
• CAS DataBase Reference: 54527-84-3(CAS DataBase Reference)

Description and Uses

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A₁, A_2A, and A₃ receptors with K_i values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC₅₀ value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca²⁺ (EC₅₀ = 0.5 μM).

Dihydropyridine calcium channel blocker. Antianginal; antihypertensive

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301+H311+H331
• Precautionary statements: P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
• Hazard Codes: T
• Risk Statements: 23/24/25
• Safety Statements: 36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: US7972100
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2933399090
• Toxicity: LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)