Novobiocin Sodium , ≥95% , 1476-53-5

Synonym(s):
Salmonella Selective Supplement;Modified Semi-solid RAPPAPORT-VASSILIADIS Selective Supplement;MSRV Selective;Novobiocin sodium salt;Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem

CAS NO.：1476-53-5

Empirical Formula: C31H35N2NaO11

Molecular Weight: 634.61

MDL number: MFCD00066541

EINECS: 216-023-6

PRODUCT Properties

• Melting point: 215-220 C
• alpha: D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H2O: soluble50mg/mL
• form: White to yellow solid
• color: white to faintly beige
• PH: 7.5 (100g/l, H2O, 25℃)
• optical activity: [α]20/D 48±3°, c = 1% in ethanol
• Water Solubility: Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol.
• Merck: 13,6755
• BRN: 3892910
• Stability: Hygroscopic

Description and Uses

Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H317-H319
• Precautionary statements: P261-P264-P280-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xi,Xn
• Risk Statements: 43-36-36/37/38-20/21/22
• Safety Statements: 36-36/37-26-37/39
• WGK Germany: 2
• RTECS: RD5425000
• F: 8-10
• HS Code: 2941 90 00
• Toxicity: LD50 orally in Rabbit: 3500 mg/kg