A6206112
Nutlin-3 , ≥98% , 548472-68-0
Synonym(s):
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one;MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem;MDM2 Inhibitor IV
CAS NO.：548472-68-0
Empirical Formula: C30H30Cl2N4O4
Molecular Weight: 581.49
MDL number: MFCD07784509
EINECS: 200-258-5
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB966.40 | In Stock |
|
| 50MG | RMB2876.80 | In Stock |
|
| 100MG | RMB4791.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >132oC (dec.) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 20 mg/mL, soluble |
| form | solid |
| pka | 14.35±0.20(Predicted) |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | BDUHCSBCVGXTJM-UHFFFAOYSA-N |
Description and Uses
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.
(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
