Nitrendipine , ≥95.0% , 39562-70-4

Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester;Nitrendipine

CAS NO.：39562-70-4

Empirical Formula: C18H20N2O6

Molecular Weight: 360.36

MDL number: MFCD00082255

EINECS: 254-513-1

PRODUCT Properties

• Melting point: 1580C
• Boiling point: 492.4°C (rough estimate)
• Density: 1.3595 (rough estimate)
• refractive index: 1.5700 (estimate)
• storage temp.: 2-8°C
• solubility: methanol: 15 mg/mL
• form: powder
• pka: 2.79±0.70(Predicted)
• color: yellow to green
• Water Solubility: Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.
• Stability: Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.

Description and Uses

Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged therapeutic effect in comparison to nifedipine makes it useful in the once to twice daily treatment of hypertension.

Antihypertensive;Calcium channel blocker

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H312-H332
• Precautionary statements: P261-P280h-P301+P312a-P304+P340-P321-P501a
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 1
• RTECS: US5653000
• Toxicity: LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann)