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A6191912

Nitidine chloride , Analysis of standards,> 98% , 13063-04-2

Synonym(s):
2,3-Dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride;NSC 146397

CAS NO.:13063-04-2

Empirical Formula: C21H18NO4+

Molecular Weight: 348.37

MDL number: MFCD00238652

EINECS: 683-192-4

Pack Size Price Stock Quantity
20MG RMB696.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 283-286 °C
storage temp.  -20°C
solubility  DMSO: soluble1mg/mL, clear (warmed)
form  powder
color  white to beige
InChIKey QLDAACVSUMUMOR-UHFFFAOYSA-M

Description and Uses

This quaternary alkaloid occurs primarily in Zanthoxylum nitidum (Lam.) DC but has also been found in several species of Fagara. It is normally isolated as the chloride which forms bright yellow needles when recrystallized from EtOH-HCl. The crystals decompose on heating to 240°C yielding a product having m.p. 285-6°C. The iodide also forms yellow needles and undergoes a similar trans_x0002_formation at the same temperature to yield a product with the same melting point, possibly identical to that obtained from the chloride. The crystalline acetate, m.p. 255-260°C and the pseudocyanide, m.p. 215-6°C and decomposing completely at 234°C in vacuo have also been prepared. A periodide, which fonns chocolate-brown needles when crystallized from Me2CO, m.p. 300-1 °c (dec.) is useful for characterizing the base.

Nitidine Chloride shows the ability to inhibit hepatic cancer growth through modulation of signaling pathways.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
Safety Statements  24/25
WGK Germany  3
RTECS  DF4935500
HS Code  29399990
Toxicity mouse,LD50,intraperitoneal,98980ug/kg (98.98mg/kg),National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,

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