Niclosamide , Analysis standard , 50-65-7

Synonym(s):
2′,5-Dichloro-4′-nitrosalicylanilide;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide, mTOR Inhibitor IX, Autophagy Inducer III, STAT3 Inhibitor XV, Wnt Pathway Inhibitor XIII;Niclosamide - CAS 50-65-7 - Calbiochem

CAS NO.：50-65-7

Empirical Formula: C13H8Cl2N2O4

Molecular Weight: 327.12

MDL number: MFCD00057597

EINECS: 200-056-8

PRODUCT Properties

• Melting point: 225-230°
• Boiling point: 424.5±45.0 °C(Predicted)
• Density: 1.6646 (rough estimate)
• refractive index: 1.6200 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: acetone: methanol: soluble50mg/mL (methanol:acetone (1:1))
• pka: 7.45±0.43(Predicted)
• form: Pale yellow solid
• color: Yellow
• Water Solubility: 13.32mg/L(25 ºC)
• BRN: 2820605
• BCS Class: 4
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChIKey: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
• CAS DataBase Reference: 50-65-7(CAS DataBase Reference)
• EPA Substance Registry System: Niclosamide (50-65-7)

Description and Uses

Niclosamide (50-65-7) reversibly inhibits mTORC1 signaling and stimulates autophagy.1 Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Niclosamide inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3.2

An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.

Safety

• Symbol(GHS): GHS09
• Signal word: Warning
• Hazard statements: H400
• Precautionary statements: P273-P391-P501
• Risk Statements: 50
• Safety Statements: 29
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 2
• RTECS: VN8400000
• HS Code: 29242990
• Hazardous Substances Data: 50-65-7(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: 2500mg/kg