A6181812
Norfloxacin , Analysis standard , 70458-96-7
Synonym(s):
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid;Norfloxacin
CAS NO.：70458-96-7
Empirical Formula: C16H18FN3O3
Molecular Weight: 319.33
MDL number: MFCD00079532
EINECS: 274-614-4
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB715.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 220°C |
| Boiling point: | 555.8±50.0 °C(Predicted) |
| Density | 1.2504 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Very slightly soluble in water, slightly soluble in acetone and in ethanol (96 per cent). |
| form | Crystalline Powder |
| pka | pKa1 6.34; pKa2 8.75(at 25℃) |
| color | White to yellow |
| Water Solubility | Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water |
| Merck | 14,6700 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23) |
| InChIKey | OGJPXUAPXNRGGI-UHFFFAOYSA-N |
| SMILES | N1(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C(=O)C(C(O)=O)=C1 |
| CAS DataBase Reference | 70458-96-7(CAS DataBase Reference) |
| EPA Substance Registry System | 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)- (70458-96-7) |
Description and Uses
Norfloxacin is the first of the third generation nalidixic acid analogs to reach the marketplace. It exhibits potent in vitro and in vivo activity against Pseudomonas, enteric gram-negative rods and gram-positive cocci. Norfloxacin is orally effective in the treatment of urinary tract infections, including those due to organisms refractory to many other agents.
Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-37/39-24/25 |
| WGK Germany | 2 |
| RTECS | VB2005000 |
| HazardClass | IRRITANT |
| HS Code | 29335990 |
| Hazardous Substances Data | 70458-96-7(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (mg/kg): >4000 orally (both species); 1500 s.c. (both species); 470, >500 i.m.; 220, 270 i.v. (Irikura) |
