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A6181812

Norfloxacin , Analysis standard , 70458-96-7

Synonym(s):
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid;Norfloxacin

CAS NO.:70458-96-7

Empirical Formula: C16H18FN3O3

Molecular Weight: 319.33

MDL number: MFCD00079532

EINECS: 274-614-4

Pack Size Price Stock Quantity
100MG RMB715.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 220°C
Boiling point: 555.8±50.0 °C(Predicted)
Density  1.2504 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Very slightly soluble in water, slightly soluble in acetone and in ethanol (96 per cent).
pka pKa1 6.34; pKa2 8.75(at 25℃)
form  Crystalline Powder
color  White to yellow
Water Solubility  Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water
Merck  14,6700
Stability: Hygroscopic
InChI InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
InChIKey OGJPXUAPXNRGGI-UHFFFAOYSA-N
SMILES N1(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C(=O)C(C(O)=O)=C1

Description and Uses

Norfloxacin is the first of the third generation nalidixic acid analogs to reach the marketplace. It exhibits potent in vitro and in vivo activity against Pseudomonas, enteric gram-negative rods and gram-positive cocci. Norfloxacin is orally effective in the treatment of urinary tract infections, including those due to organisms refractory to many other agents.

Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-37/39-24/25
WGK Germany  2
RTECS  VB2005000
HazardClass  IRRITANT
HS Code  29335990
Toxicity LD50 in mice, rats (mg/kg): >4000 orally (both species); 1500 s.c. (both species); 470, >500 i.m.; 220, 270 i.v. (Irikura)

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