(±)-Nornicotine , 98% , 5746-86-1
Synonym(s):
(±)-Nornicotine;2-(3-Pyridyl)pyrrolidine;3-(2-Pyrrolidinyl)pyridine
CAS NO.：5746-86-1
Empirical Formula: C9H12N2
Molecular Weight: 148.21
MDL number: MFCD00016913
EINECS: 637-353-0
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB23.20 | In Stock |
|
| 50MG | RMB33.60 | In Stock |
|
| 100mg | RMB47.20 | In Stock |
|
| 250MG | RMB70.40 | In Stock |
|
| 1g | RMB173.60 | In Stock |
|
| 5g | RMB957.60 | In Stock |
|
| 25g | RMB3107.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 235-236 °C(Solv: ethanol (64-17-5)) |
| Boiling point: | 107-108°C 2mm |
| Density | 1,074 g/cm3 |
| refractive index | 1.54 |
| Flash point: | 101°C |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | liquid |
| pka | 9.09±0.10(Predicted) |
| color | yellow |
| Specific Gravity | 1.074 |
| Water Solubility | Soluble in acetone, chloroform and water (50mg/ml). |
| Merck | 14,6712 |
| BRN | 81968 |
| Stability: | Hygroscopic, Light Sensitive, Moisture Sensitive |
| CAS DataBase Reference | 5746-86-1(CAS DataBase Reference) |
Description and Uses
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 μM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine.
3-(2-Pyrrolidinyl)pyridine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 |
| Hazard Codes | Xn,Xi,T,F |
| Risk Statements | 20/21/22-36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36/37-45-16-7 |
| RIDADR | 2810 |
| WGK Germany | 3 |
| RTECS | QS6350000 |
| F | 3-10 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29399990 |
| Toxicity | LDLo ipr-rat: 6 mg/kg AJEBAK 25,83,47 |
