Home Categories Organic Chemistry 1-Naphthol
A6154212

1-Naphthol , Analysis standard , 90-15-3

Synonym(s):
α-Naphthol;1-Hydroxynaphthalene;1-Naphthol;Duloxetine impurity D (PhEur)

CAS NO.:90-15-3

Empirical Formula: C10H8O

Molecular Weight: 144.17

MDL number: MFCD00003930

EINECS: 201-969-4

Pack Size Price Stock Quantity
1G RMB199.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 94-96 °C(lit.)
Boiling point: 278-280 °C(lit.)
Density  1.224
vapor density  4.5 (120 °C, vs air)
vapor pressure  1 mm Hg ( 94 °C)
refractive index  1.6224
Flash point: 125 °C
storage temp.  Store below +30°C.
solubility  Soluble in benzene, chloroform, ether and ethanol.
pka 9.34(at 25℃)
form  Crystalline Flakes
color  white to off-white
Odor Slight phenolic odor
explosive limit 5%
Water Solubility  436.7mg/L(25 ºC)
λmax 324nm(MeOH)(lit.)
Sensitive  Air & Light Sensitive
Merck  14,6383
BRN  1817321
Stability: Stable, but air and light sensitive - store under inert gas. Incompatible with strong bases, strong oxidizing agents.
InChIKey KJCVRFUGPWSIIH-UHFFFAOYSA-N
LogP 2.84 at 25℃

Description and Uses

1-Naphthol, or α-naphthol, is a fluorescent organic compound with the formula C10H7OH. It is a white solid. It is an isomer of 2-naphthol differing by the location of the hydroxyl group on the naphthalene ring. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. Both isomers are soluble in simple alcohols, ethers, and chloroform. They are precursors to a variety of useful compounds. Naphthols (both 1 and 2 isomers) are used as biomarkers for livestock and humans exposed to polycyclic aromatic hydrocarbons.
α-naphtol, combined with epichlorhydrine and sodium hydroxide to form alpha-naphtyl glycidyl ether, caused sensitization in one of three workers in a chemical plant.

1-Naphthol is used as a precursor in the manufacturing of various azo dyes and pharmaceuticals such as nadolol. It is used as biomarkers. It is used in analytical chemistry as Molisch's reagent (1-naphthol dissolved in ethanol) for checking the presence of carbohydrates. It plays an essential role with sodium hypobromite to detect the presence of arginine in proteins, which is called as Sakaguchi test.

Safety

Symbol(GHS) 
GHS05,GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H311-H315-H317-H318-H335-H371-H410
Precautionary statements  P273-P280-P301+P312-P302+P352+P312-P305+P351+P338-P308+P311
Hazard Codes  Xn,N
Risk Statements  21/22-37/38-41-51/53
Safety Statements  22-26-37/39-2-61
RIDADR  UN 2811 6.1/PG 3
WGK Germany  1
RTECS  QL2800000
8-23
Autoignition Temperature 510 °C
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29071510
Toxicity LD50 orally in Rabbit: 1870 mg/kg LD50 dermal Rabbit 880 mg/kg

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