Mometasone Furoate , >98.0%(HPLC) , 83919-23-7
Synonym(s):
(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione;9α,21-dichloro-11β-hydroxy-16α-methyl 3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate;Mometasone furoate
CAS NO.：83919-23-7
Empirical Formula: C27H30Cl2O6
Molecular Weight: 521.43
MDL number: MFCD00866003
EINECS: 617-501-0
| Pack Size | Price | Stock | Quantity |
| 250MG | RMB534.40 | In Stock |
|
| 1G | RMB1802.40 | In Stock |
|
| 5G | RMB5973.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 218-220°C |
| alpha | D26 +58.3° (dioxane) |
| Boiling point: | 655.5±55.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 13.02±0.70(Predicted) |
| form | powder |
| color | white to off-white |
| optical activity | [α]/D +50 to +60°, c = 0.5 in methanol |
| InChIKey | WOFMFGQZHJDGCX-ZULDAHANSA-N |
| SMILES | C[C@]12C[C@H](OC(=O)C3=CC=CO3)C3([C@](CCC4[C@]3(C)C=CC(=O)C=4)([H])[C@]1([H])C[C@@H](C)[C@]2(OC(=O)C1OC=CC=1)C(=O)CCl)Cl |&1:1,3,13,17,25,28,30,r| |
| CAS DataBase Reference | 83919-23-7(CAS DataBase Reference) |
Description and Uses
Mometasone furoate is a topical steroidal antiinflammatory useful in the treatment of corticosteroid-responsive dermatoses. As a steroidal antiinflammatory of grade II potency, mometasone furoate is characterized by a once-daily dose regimen and a relatively wide safety margin.
Mometasone furoate is a deuterated topical corticosteroid used as an anti-inflammatory. Mometasone furoate has been used to study its effect on Leishmania major amastigotes. It could as labeled Mometasone, intended for use as an internal standard for the quantification of Mometasone by GC- or LC-mass spectrometry. Formulations containing mometasone furoate have been used in the treatment of allergic rhinitis, atopic dermatitis, and asthma. Intranasal administration of mometasone furoate (1 μg/nostril) reduces the frequency of sneezing and nasal rubbing in a rat model of histamine-induced allergic rhinitis. Topical application of mometasone furoate reduces croton oil-induced ear edema in mice (ED50 = 0.31 μg/ml).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| WGK Germany | 3 |
| HS Code | 29372290 |
