Mefloquine Hydrochloride , >98.0%(HPLC) , 51773-92-3

Synonym(s):
(AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride;Mefloquine hydrochloride;MQ

CAS NO.：51773-92-3

Empirical Formula: C17H17ClF6N2O

Molecular Weight: 414.77

MDL number: MFCD00797519

EINECS: 257-412-0

PRODUCT Properties

• Melting point: 250-254?C
• storage temp.: 2-8°C
• solubility: DMSO: 38 mg/mL, soluble
• form: solid
• color: white
• λmax: 222nm(Acidic H2O)(lit.)
• Merck: 14,5801
• BCS Class: 4/2
• Stability: Temperature Sensitive
• InChI: InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3
• InChIKey: WESWYMRNZNDGBX-YLCXCWDSSA-N
• SMILES: C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl |&1:5,7,r|
• CAS DataBase Reference: 51773-92-3(CAS DataBase Reference)

Description and Uses

Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria. Administered once weekly, the combination is effective against pathogens resistant to other agents.

Antimalarial;Heme polymerase inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: VC0308000
• HS Code: 2933399090