Marbofloxacin , 98% , 115550-35-1

Synonym(s):
9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-piperazino)-7-oxo-7H-pyrido[1,2,3-ij][1,2,4]benzoxadiazine-6-carboxylic acid;Zeniquin

CAS NO.：115550-35-1

Empirical Formula: C17H19FN4O4

Molecular Weight: 362.36

MDL number: MFCD00864820

EINECS: 640-416-5

PRODUCT Properties

• Melting point: 268-269°C (dec.)
• Boiling point: 571℃
• Density: 1.55±0.1 g/cm3(Predicted)
• Flash point: >110°(230°F)
• storage temp.: Inert atmosphere,2-8°C
• solubility: Chloroform (Slightly, Heated)
• pka: 6.02±0.20(Predicted)
• form: Solid
• color: Light Yellow
• Water Solubility: Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at <1mg/ml
• Merck: 14,5750
• InChI: InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)
• InChIKey: BPFYOAJNDMUVBL-UHFFFAOYSA-N
• SMILES: N12C=C(C(O)=O)C(=O)C3=C1C(=C(N1CCN(C)CC1)C(F)=C3)OCN2C

Description and Uses

Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml). It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 μg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively. In vivo, the administration of marbofloxacin (2 mg/kg, i.m.) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia. Oral marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%. Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.

A broad spectrum antibiotic commonly used to target Pseudomonas and Staphylococci species

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H412
• Precautionary statements: P273-P501
• Hazard Codes: Xi
• Risk Statements: 52/53-36/37/38
• Safety Statements: 61-36-26-60
• WGK Germany: 2
• RTECS: UU8815140
• HS Code: 29349990